Kursplan

COURSE TITLE

Medical Genetcis, 7,5 points

COURSE CATEGORY   Programkurs/Fristående kurs
MAIN FIELD OF STUDY
SUBJECT AREA

COURSE CODE

OMBGEN

AIM OF THE COURSE

The aim of the course is to provide the students with advanced theoretical and methodological knowledge in medical genetics.

CONTENTS

* Inheritance of, and molecular mechanisms involved in, monogenic and polygenic traits and diseases. The interplay between genteic and environmental factors.
* Genetic variation in populations, calculation of ellele frequencies, understanding concepts within evolution and population genetics.
* Molecular epidemiology; calculations of associations and risks from genetic data.
* Gene-ethical issues.
* Theory and practice of laboratory and computer-based methods in modern molecular genetics.

Genomic evolution: Evolutionary aspects on mitochondria-DNA, transposons and gene conversion, evolution in coding and non-coding DNA and evolution in human sex chromosomes.

Population genetics: Genetic variation in populations (e.g. screening for polymorphism in different loci in a population) and between different populations. Medical aspects on migration of polymorphic loci in a population, including loci of importance for human health (e.g. genes predisposing for diseaese or ability to metabolize drugs). Phylogeny on genetic and individual level and how to use bioinformatic for studying phylogeny.

Genetic toxicology: How different compounds are metabolized and how they interact with DNA.

Medical and Clinical Genetics: Molecular mechanisms leading to tumour development end other genetic diseases.

TEACHING

The course consist of lectures, tutorial groups, seminars and laboratory works.

The educational method used is problem-based learning (PBL). PBL emphasises the student´s development of free, self-supporting, lifelong learning ability as an instrument for critical inquiry. The students own queries and formulated problems form the basis of PBL. Important is also the student´s ability to take responsibility for his/her own learning, and to seek and evaluate information and knowledge and to train co-operation and flexible attitude to different views and ideas.

EXAMINATION

Active participation in tutorial groups, laboratory works and seminars. Writing and oral presentation of assignments.

Students, which have not passed on the regular examination occasion, are normally offered four additional opportunities according to this syllabus, one of which is close in time to the first examination occasion. Students who have failed three times on the course or part of the course are entitled to request another examiner at the new examination occasion.

ADMISSION REQUIREMENTS

Bachelor of Science in Biomedicine or other related subjects such as Medicine or Biology. At least three years of full-time undergraduate studies in a relevant main subject. For students in the Medical Biology Programme, 160 credits: Passed semester 1 to 5.
Obs! To be admitted to courses taught in English you must fulfil the requirement of at least one year of full-time undergraduate studies. Documented knowledge of English equivalent to "Engelska B" is required, or an international proficiency test, e.g. TOEFL, minimum score 550/213.

GRADING

CERTIFICATE

COURSE LITERATURE

The course literature is decided upon by the department in question.

OTHER INFORMATION

Medical Genetcis
Medical Genetics

Department responsible
for the course or equivalent: MEDBIO - Medicinsk biologi

Registrar No:

Course Code: OMBGEN

Exam codes: see Local Computer System

Subject/Subject Area :

Level		Education level			Subject Area Code		Field of Education
D							Naturvetenskap