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COURSE TITLE

Tumour Biology, 7,5 points

COURSE CATEGORY   Single subject course MAIN FIELD OF STUDY   Medical Biology SUBJECT AREA   Medical Biology   COURSE CODE   8FA229

AIM OF THE COURSE

The purpose of the course is for the students to obtain advanced knowledge about tumour development in general including the genetic basis of human cancer. Furthermore, the course will give an overview of cancer by site taking into account different clinical and biological aspects as well as the occurrence of specific gene alterations. The course is elective semester one or three in the Master’s Programme in Experimental and Medical Biosciences. LEARNING OUTCOMES By the end of the course the students will be able to: Knowledge and understanding - Analyze and discuss specific capabilities of cancer cells and how the biological/genetic alterations occur for normal cell to tumor cell - Integrate knowledge in tumour biology in different types of malignancies in relation to environmental factors, gender, age, hormonal influence, and molecular alterations Competence and skills - Design an experiment in order to analyse how the alterations in cell signalling may interfere with the cellular response to damage Judgement and approach - Analyze and assess experimental results in tumour biology - Evaluate and discuss new hypotheses in the field of cancer research

CONTENTS

- Organ specific cancer: different spectra of malignancies in relation to race, gender, age, and molecular biology - Mechanisms of tumour development, invasion and metastasis - Concepts in cancer genetics including oncogene, tumour suppressor gene, mismatched repaired genes, and apoptosis related genes - Control of the cell cycle and cancer - Angiogenesis and cancer - Hormones and cancer - Stem cells and cancer - Tumour immunology - The principle of tumour diagnosis and treatment

TEACHING

General: Linköping University Master’s Programme in Experimental and Medical Biosciences applies student-centered learning among which Problem Based Learning (PBL) is one pedagogical philosophy and method. To prepare the students for future employment, practical and experimental work in laboratory settings are important parts of the programme in courses as well as in individual projects. Specific: In this course lectures, tutorial groups, seminars, and laboratory work are used.

EXAMINATION

COMPULSORY ITEMS Active participation in the compulsory parts is necessary to pass the course, and assessment of them is carried out continuously. Compulsory parts in this course are: tutorial groups, laboratory work, and seminars. EXAMINATION Individual written examination. Individual written report of laboratory work. SCOPE OF RE-EXAMINATION The extent of a re−examination shall be similar to the regular examination. CHANGE OF EXAMINERS Students who have failed the course or part of the course twice are entitled to request another examiner for the following examination occasion, unless specific reasons are present. REGISTRATION FOR EXAMINATION The procedure for registration should be stated prior to the commencement of each course. In other respects, regulations concerning examination and examiners are applied in accordance with Linköping University policy.

ADMISSION REQUIREMENTS

At least three years of full-time undergraduate studies (180 credits) in a major subject area with relevance for biomedical sciences. This could include previous studies at faculties of medicine, technology/natural sciences, odontology or veterinary medicine. A major part of courses (90 credits) should be in subjects such as biochemistry, cell biology, molecular biology, genetics, gene technology, microbiology, immunology, histology, anatomy, and pathology. The lowest acceptable grade from undergraduate studies is Pass. Applicants must also have documented knowledge of English equivalent to Engelska B/Engelska 6; i.e. an internationally recognized test, e.g. TOEFL (minimum scores: Paper based 575 + TWE-score 4.5, and internet-based: Score of 20 (scale 0-30) in written test, total score of 90), IELTS, academic (minimum score: Overall mark of 6.5 and no section below 5.5), or equivalent.

GRADING

The course is graded on the following scale: Pass; Fail.

CERTIFICATE

Course certificates are issued by the Board of the Faculty of Health Sciences when requested by the student.

COURSE LITERATURE

The course literature is decided upon by the department in question.

OTHER INFORMATION

The planning and implementation of a course must take its starting point in the wording of the course plan. The course evaluation included in each course must therefore take up the question how well the course agrees will the course plan. The course is carried out in such a way that both men’s and women’s experience and knowledge is made visible and developed. If the course is withdrawn, or is subject to major changes, examinations according to this course plan are normally offered on a total of three occasions within one year, one of them in close connection to the first examination.

Tumour Biology Tumörbiologi   Department responsible for the course or equivalent: IKE- Institutionen för Klinisk och Experimentell medicin             Registrar No:   Course Code: 8FA229           Exam codes: see Local Computer System       Subject/Subject Area : Medical Biology                       Level   Education level     Subject Area Code   Field of Education         MB1   Medicine