| TFTB32 |
Design of Biotechnical Process and Production Systems, Project Course, 6 ECTS credits.
/Projektkurs i design av biotekniska process- och produktionssystem (CDIO)/
For:
KeBi
TB
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Prel. scheduled
hours: 44
Rec. self-study hours: 116
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Area of Education: Technology
Main field of studies: Engineering Biology
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Advancement level
(G1, G2, A): A
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Aim:
Project course accomplishing engineering skills in analysis and design of industrial bioprocesses in evaluating production and process economical prerequisites. Understand how to use common process design tools.
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Prerequisites: (valid for students admitted to programmes within which the course is offered)
Industrial biotechnology course is a prerequisite. It is also a prerequisite to attend the following courses that are given in parallel with the course; Biotechnical production systems; Biotechnology manufacturing; Pharmaceutical Development; Quality Management.
Note: Admission requirements for non-programme students usually also include admission requirements for the programme and threshhold requirements for progression within the programme, or corresponding.
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Organisation:
The students should in groups of 4-5 persons implement the knowledge presented in the courses on Industrial biotechnology, Biotechnical production systems; Biotechnology manufacturing; Pharmaceutical Development; Quality Management. The framework is a project assignment based on industrial design issues within biotech industry. The project model CDIO (Conceive, Design, Implement and Operate) is used. The assignments resemble the work performed by industrial consultancy teams to their customers or at R&D departments of large companies. The projects contain two phases, the first centers in on the conception of the aims and means for the design and the second on development of a process for production. The latter is referred to as the design phase intended to describe the process/production as it is implemented and operated.
CDIO principles are applied (especially planning, develop, implementing and testing of process solutions). Project groups (4-5 members) are organized and a specified engineering design assigment is allotted to each group which requires the development of group activities based on the curricula in parallel courses.
The course runs over the entire spring semester.
Please note that the courses TMMT03 and TFTB39 should be taken during the same semester as TFTB32.
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Course contents:
Follows the specified assignment to the group. This may include total production systems. Raw material supply. Just-in-time principles. Quality systems. Reaction engineering. Unit operations up- and downstream. Process modelling and use of biomechatronic methodology. Process economical evaluation. In-process analysis aspects. Total Quality Management and Process analytical technology (PAT). Process validation.
The design shall contain at detailed description of the product and its production. Calculations and modelling of the process operations are a necessity in presenting how the process will behave when implemented. The volumes, batches, yields, material flows and operations shall be presented and scheduled. Process descriptions are presented in flow schedules �?ohour by hour�?�. Estimations are presented in diagrams and tables.
Economy and resources: The chosen process is calculated based on mass balances, raw materials, operations, investments, personnel etc. The calculations are used to present the financial framework of the process/production over the complete intended time span of the production. Estimations should be presented and explained in tables/diagrams and commented in general text.
Quality management: The needs for quality assessments and controls are presented in reference to the technical and regulatory demands that are integral to the production of the product category.
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Course literature:
Literature from the following courses: Industrial biotechnology, Biotechnical production systems, Biotechnology manufacturing, Biotechnology and Pharmaceuticals, and Quality Management and Engineering
Literature acquired through Searches in databases is essential in the development of the projects.
Reference literature; Biomechatronic Design in Biotechnology. Carl-Fredrik Mandenius and Mats Björkman. Wiley 2011.
Basic Biotechnology. Colin Ratledge and Björn Kristiansen. 3d edition. Cambridge University Press 2006.
Bioseparations Science and Engineering. Second Edition. Roger G. Harrison, Paul W. Todd, Scott R. Rudge, and Demetri P. Petrides. Oxford University Press 2015.
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Examination: |
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Project
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6 ECTS
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Course language is Swedish.
Department offering the course: IFM.
Director of Studies: Magnus Boman
Examiner: Gunnar Hörnsten
Course Syllabus in Swedish
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