| NBID64 |
Molecular Physiology and Cell Signaling Mechanisms, 6 ECTS credits.
/Molekylärfysiologi och cellsignaleringsmekanismer/
For:
Bio
KeBi
PRO
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Prel. scheduled
hours: 48
Rec. self-study hours: 112
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Area of Education: Science
Main field of studies: Biology, Chemical Biology
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Advancement level
(G1, G2, A): A
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Aim:
The student will increase her/his understanding of the role of selected molecules on the function of the human body by focusing on the relationship between molecular structure and intracellular function.
The student will develop a proficiency in finding, evaluating and compiling primary and secondary research literature on a specific topic.
The student will improve her/his skills in summarizing and communicating the results of her/his own experimental results and those of others in both written and oral form.
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Prerequisites: (valid for students admitted to programmes within which the course is offered)
120 ECTS including 90 ECTS in biology and a course in Molecular Genetics.
Note: Admission requirements for non-programme students usually also include admission requirements for the programme and threshhold requirements for progression within the programme, or corresponding.
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Organisation:
The course is composed by formal lectures, laboratory exercises and seminars , each with its own evaluation scheme. The lectures are based on primary research articles and reviews of which the most relevant ones (between 1-3 per 2h lecture) will be provided as study material. All lectures will be available to the students through Blackboard, the Learning Management System used at Linköping universitet. The laboratory exercises are linked to some of the lectures and require the writing of a lab report using quantitative methods. Attendance to the labs is compulsory. The seminars deal with generic aspects in modern biomedical research namely the use of model species and the need to balance reductionistic studies with systems biology approaches. The seminars require the discussion in smaller groups of scientific articles related with the topics.
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Course contents:
The course is centered around different molecules or families of molecules that are relevant to the function of the human body and also its pathology, namely:
- Erythropoietin and nitric oxide involved in oxygen transport and vascular regulation
- Voltage gated potassium channels involved in neuronal and cardiac excitability and associated to long QT syndrome and sudden death
- Voltage gated calcium channels and calcium pumps (ryanodine receptor and sarcoplasmic reticulum calcium ATPase) involved in muscle contraction and relaxation and associated to malignant hyperthermia
- G-protein coupled receptors, with special emphasis on beta-adrenergic receptors and angiotensin receptors. Involved in cardiovascular regulation and fluid homeostasis
- Epithelial sodium channels, involved in cardiorenal regulation
- Transient-receptor potential channels (TRP) involved in sensory transduction of temperature, pain and mechanical stimulus
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Course literature:
As recommended (but not compulsory) textbook, the following book is relevant: Boron, W. F. & Boulpaev, E. L. Medical Physiology. A cellular and molecular approach 2nd edition (Saunders, Elsevier Science, Philadelphia, 2008).
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Examination: |
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Written examination
Seminar attendance and discussion
Report of laboratory exercises
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2 ECTS
1 ECTS
3 ECTS
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The final grade is a combination of all grades where TEN1 counts for 40 %, UPG3 10% and UPG5 50%. |
Course language is English.
Department offering the course: IFM.
Director of Studies: Agneta Johansson
Examiner: Jordi Altimiras
Link to the course homepage at the department
Course Syllabus in Swedish
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