NBID49 Molecular Physiology 2011

Study Guide@lith

Valid for year : 2011

NBID49	Molecular Physiology, 7,5 ECTS credits. /Molekylärfysiologi/ For: MOL
	Prel. scheduled hours: 60 Rec. self-study hours: 140
	Area of Education: Science Main field of studies: Biology, Chemical Biology
	Advancement level (G1, G2, A): A
	Aim: The student will increase her/his understanding of the role of selected molecules on the function of the human body by focusing on the relationship between molecular structure and intracellular function. The student will develop a proficiency in finding, evaluating and compiling primary and secondary research literature on a specific topic. The student will improve her/his skills in summarizing and communicating the results of her/his own experimental results and those of others in both written and oral form.
	Prerequisites: (valid for students admitted to programmes within which the course is offered) Admittance to master programme in molecular biology/protein science. Passed basic subjects in biology (75hp, at least 40hp theory) Understanding of the following essential physiological concepts as presented in �?oSilverthorn, D. U. Human Physiology. An integrated approach (Pearson, Benjamin Cummings, San Francisco, 2007)": Homeostasis Negative feedback control loops Resting membrane potential Ionic basis of the action potential: fluxes of sodium and potassium Ultrastructure of the synaptic cleft and dynamics of neurotransmitter release, reuptake and degradation Microscopic structure of a muscle cell Cross-bridge cycling in muscle: role of actin and myosin Dynamics of calcium in muscle contraction Muscle types: skeletal, cardiac and smooth Oxygen dissociation curve of the hemoglobin Structure of a nephron Essential pathways of cellular activation and intracellular second messengers: cAMP, IP3 and calcium Note: Admission requirements for non-programme students usually also include admission requirements for the programme and threshhold requirements for progression within the programme, or corresponding.
	Supplementary courses: Adaptation: molecules to organisms
	Organisation: The course is composed by formal lectures, laboratory exercises and seminars , each with its own evaluation scheme. The lectures are based on primary research articles and reviews of which the most relevant ones (between 1-3 per 2h lecture) will be provided as study material. All lectures will be available to the students through Blackboard, the Learning Management System used at Linköping universitet. The laboratory exercises are linked to some of the lectures and require the writing of a lab report using quantitative methods. Attendance to the labs is compulsory. The seminars deal with generic aspects in modern biomedical research namely the use of model species and the need to balance reductionistic studies with systems biology approaches. The seminars require the discussion in smaller groups of scientific articles related with the topics.
	Course contents: The course is centered around different molecules or families of molecules that are relevant to the function of the human body and also its pathology, namely: Erythropoietin and nitric oxide involved in oxygen transport and vascular regulation Voltage gated potassium channels involved in neuronal and cardiac excitability and associated to long QT syndrome and sudden death Voltage gated calcium channels and calcium pumps (ryanodine receptor and sarcoplasmic reticulum calcium ATPase) involved in muscle contraction and relaxation and associated to malignant hyperthermia G-protein coupled receptors, with special emphasis on beta-adrenergic receptors and angiotensin receptors. Involved in cardiovascular regulation and fluid homeostasis Epithelial sodium channels, involved in cardiorenal regulation Transient-receptor potential channels (TRP) involved in sensory transduction of temperature, pain and mechanical stimulus
	Course literature: As recommended (but not compulsory) textbook, the following book is relevant: Boron, W. F. & Boulpaev, E. L. Medical Physiology. A cellular and molecular approach 2nd edition (Saunders, Elsevier Science, Philadelphia, 2008).
	Examination:
	Written examination Seminar attendance and discussion Report of laboratory exercises Written summary of scientific articles	2 ECTS 1 ECTS 3 ECTS 1,5 ECTS

	The final grade is a combination of all grades where TEN1 counts for 40 %, UPG3 10% and UPG5 50%.
Course language is English. Department offering the course: IFM. Director of Studies: Agneta Johansson Examiner: Jordi Altimiras Link to the course homepage at the department Course Syllabus in Swedish

Linköping Institute of Technology
Contact: TFK , val@tfk.liu.se Last updated: 06/11/2015