NBID21 Molecular Physiology 2007

Study Guide@lith

Valid for year : 2007

NBID21	Molecular Physiology, 6 ECTS credits. /Molekylärfysiologi/ For: Bio KeBi MOL PRO
	Prel. scheduled hours: 60 Rec. self-study hours: 100
	Area of Education: Science Subject area: Biology
	Advancement level (G1, G2, A): A
	Aim: The student will increase her/his understanding of the role of selected molecules on the function of the human body by focusing on the relationship between molecular structure and intracellular function. The student will develop a proficiency in finding, evaluating and compiling primary and secondary research literature on a specific topic. The student will improve her/his skills in summarizing and communicating the results of her/his own experimental results and those of others in both written and oral form.
	Prerequisites: (valid for students admitted to programmes within which the course is offered) Passed basic subjects in biology (50p, at least 25p theory) Understanding of the following essential physiological concepts as presented in �?oSilverthorn, D. U. Human Physiology. An integrated approach (Pearson, Benjamin Cummings, San Francisco, 2007)": Homeostasis Negative feedback control loops Resting membrane potential Ionic basis of the action potential: fluxes of sodium and potassium Ultrastructure of the synaptic cleft and dynamics of neurotransmitter release, reuptake and degradation Microscopic structure of a muscle cell Cross-bridge cycling in muscle: role of actin and myosin Dynamics of calcium in muscle contraction Muscle types: skeletal, cardiac and smooth Oxygen dissociation curve of the hemoglobin Structure of a nephron Essential pathways of cellular activation and intracellular second messengers: cAMP, IP3 and calcium Note: Admission requirements for non-programme students usually also include admission requirements for the programme and threshhold requirements for progression within the programme, or corresponding.
	Supplementary courses: NBID24 Adaptation: molecules to organisms, NBID27 Neurobiology
	Organisation: The course is composed by formal lectures, laboratory exercises and a literature assignment, each with its own evaluation scheme. The lectures are based on primary research articles and reviews of which the most relevant ones (between 1-3 per 2h lecture) will be provided as study material. All lectures will be available to the students through Blackboard, the Learning Management System used at Linköping universitet. The laboratory exercises are linked to some of the lectures and require the writing of a lab report using quantitative methods. Attendance to the labs is compulsory. The literature assignment in small groups will be presented orally to all other fellow students.
	Course contents: The course is centered around different molecules or families of molecules that are relevant to the function of the human body and also its pathology, namely: Hemoglobin, erythropoietin and nitric oxide involved in oxygen transport and vascular regulation Voltage gated potassium channels involved in neuronal and cardiac excitability and associated to long QT syndrome and sudden death Voltage gated calcium channels and calcium pumps (ryanodine receptor and sarcoplasmic reticulum calcium ATPase) involved in muscle contraction and relaxation and associated to malignant hyperthermia G-protein coupled receptors, with special emphasis on beta-adrenergic receptors and angiotensin receptors. Involved in cardiovascular regulation and fluid homeostasis Epithelial sodium channels, involved in cardiorenal regulation Transient-receptor potential channels (TRP) involved in sensory transduction of temperature, pain and mechanical stimulus
	Course literature: As recommended (but not compulsory) textbook, the following is suggested Boron, W. F. & Boulpaev, E. L. Medical Physiology. A cellular and molecular approach (Saunders, Elsevier Science, Philadelphia, 2003).
	Examination:
	Written examination Essay report and presentation Report of laboratory exercises	1,5 p 1,5 p 1,5 p	/ / /	2 ECTS 2 ECTS 2 ECTS


Course language is English. Department offering the course: IFM. Director of Studies: Agneta Johansson Examiner: Jordi Altimiras Link to the course homepage at the department Course Syllabus in Swedish

Linköping Institute of Technology
Contact: TFK , val@tfk.liu.se Last updated: 12/12/2007