| TFTB40 |
Biomedical Materials, 6 ECTS credits.
/Biomedicinska material/
For:
BME
TB
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Prel. scheduled
hours: 50
Rec. self-study hours: 110
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Area of Education: Technology
Main field of studies: Engineering Biology
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Advancement level
(G1, G2, A): A
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Aim:
This course will provide the basic knowledge of the various materials used in medicine including metals, ceramics, polymers, and composite materials used for the fabrication of medical devices and commonly used prostheses, as well as in the design and development of new materials for repair and replacement of failing or failed organs. The focus will be on polymeric biomaterials and their structure-property relationships. There will be discussions on the development of new materials that are targeted specifically to tissue engineering and regenerative medicine. The student should after this course be able to:<
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Understand the basic structure and property relationships of metal, ceramic, polymeric, biopolymeric, and composite materials systems.
Understand structure-property relationships of biological materials, including major tissues found in the body.
Be familiar with characterization methods commonly used to analyze biomaterials.
Name and describe a few specific materials in each of the main categories of materials used in medicine, such as metals, ceramics, polymers, degradable polymers, and biopolymers.
Have an understanding of the requirements for materials used in several application areas in the body, such as soft tissue replacements, hard tissue replacements, blood contacting devices, as well as transplants and tissue engineered devices.
Describe some advantages and disadvantages of different biomaterials as well as the main sterilization methods used in the medical device industry.
Describe the main degradation mechanisms of materials in the body.
Understand how to design biomaterials for certain applications as well as executing research experiments in a systematic approach (e.g. Multi-factorial design and statistical optimization) to develop new biomaterials.
Have a general understanding of the commercialization process including how to get biomaterials to the Clinic including preclinical/clinical testing as well as principles of Good Manufacturing Practice (GMP).
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Prerequisites: (valid for students admitted to programmes within which the course is offered)
Basic university level courses in chemistry, biology, physics, materials science and statistics.
Note: Admission requirements for non-programme students usually also include admission requirements for the programme and threshhold requirements for progression within the programme, or corresponding.
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Supplementary courses:
Material in Medicine (CDIO)
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Organisation:
The course is based on a combination of lectures, article review sessions, homework exercises, a potential site visit to a medical device company, and presentations of group tasks.
Article Seminars address current materials issues within the medical implant field. Each article is read, summarized and criticized during presentation/tutorial sessions. Emphasis is placed on the materials used, processing methods, characterization, and performance.
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Course contents:
The course covers the major classes of materials used in medicine, such as metals, ceramics, polymers, and composites. Structure, composition, mechanical properties, analytical methods, surface vs. bulk properties and degradation mechanisms of each material group will be reviewed with an emphasis placed on biopolymers and natural-based materials. Also covered are sterilization methods, and industry and regulatory standards required for implant materials and how to get biomaterials to patients. These aspects of biomaterials maybe further stressed in a site visit to a medical device manufacturer if feasible.
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Course literature:
Lecture and laboratory Handouts,
BIOMATERIALS SCIENCE: AN INTRODUCTION TO MATERIALS IN MEDICINE by Buddy D. Ratner, Allan S. Hoffman, Frederick J. Schoen, Jack E. Lemons, Hardcover: 864 pages Publisher: Academic Press; 2 edition (Jul 29 2004) ISBN-10: 01258246.
PRINCIPLES OF TISSUE ENGINEERING, Edited By Robert Lanza, Chief Scientific Officer, Advanced Cell Technology, MA, USA; Adjunct Professor, Institute of Regenerative Medicine, Wake Forest University School of Medicine, NC, USA Robert Lanza Advanced Cell Technology 381 Plantation Street Worcester, MA 01605, Robert Langer, Massachusetts Institute of Technology, Cambridge, U.S.A. Joseph Vacanti, Harvard Medical School and the Massachusetts General Hospital, Boston, U.S.A.
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Examination: |
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Written examination
Presentation, assigments, small project assigment
Laboratory Work and written report
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2,5 ECTS
2 ECTS
1,5 ECTS
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For the group tasks, each group of students will presents a particular application area of materials in medicine, biology or artificial tissues and organs. The application areas will be presented orally by the students during special sessions towards the middle/end of the course.
Grading is based on a final written examination, group work exercise (e.g. project report and presentation), laboratory reports, and quiz & homework. The final grade will be calculated as a weighted mean where the written examination, the group work project, the lab report, and quiz & homework gives 40%, 30%, 20%, and 10% of the final mark, respectively. Students need to get a passing mark (i.e. at least 3) in all the above to pass the course. Note that the quiz & homework is a part of the group work project (i.e. examination code UPG2). Hence, UPG2 has to total weight of 30%+10%=40%.
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Course language is English.
Department offering the course: IFM.
Director of Studies: Magnus Boman
Examiner: Mehrdad Rafat
Link to the course homepage at the department
Course Syllabus in Swedish
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