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Valid for year : 2008
 
TFKE34 Biomolecular Recognition, 6 ECTS credits.
/Biomolekylär igenkänning/

For:   KeBi   PRO  

 

Prel. scheduled hours: 120
Rec. self-study hours: 40

  Area of Education: Science

Subject area: Chemistry
  Advancement level (G1, G2, A): A

Aim:
The course goal is to give the students a deep knowledge about structure/function relations in bio-molecular systems. Special emphasis is put on bio-molecular interactions and on molecular mechanisms in enzymatic catalysis. After the course the student is expected to:
  • Master important methods and theories that describe dynamics in bio-molecular systems
  • Master central concepts and theories for molecular interactions and for reaction mechanisms
  • Have good skills to communicate bioorganic research problems, methods and results
  • Have the ability to critically read advanced literature within the field.


Prerequisites: (valid for students admitted to programmes within which the course is offered)
Admittance to the course requires that the course Biochemistry 2 is approved or corresponding knowledge.

Note: Admission requirements for non-programme students usually also include admission requirements for the programme and threshhold requirements for progression within the programme, or corresponding.
Organisation:
The course will contain a mix of lectures, demonstrations and student led seminars. All educational subsections are compulsory.

Course contents:
A. The course includes theory on:
  • Bio-molecular dynamics,
  • Analysis of complex kinetics and identification of intermediates,
  • Enzymatic catalysis including the relations between the organisation of the active site and the catalytic activity,
  • Interactions between enzyme and substrate with emphasis on electrostatic and hydrophobic effects,
  • Inhibitors and their structure and function,
  • Co-operativity and allostery,
The section on molecular modelling includes use of software for use molecular dynamics in the studies of bio-molecules and their interactions with substrates.

Course literature:
�?oStructure and mechanism in protein science, a guide to enzyme catalysis and protein folding�?� by A. Fersht. Publisher: W.H. Freeman and Company. ISBN 0-7167-3268-8

Examination:
Written examination
 6 ECTS
 


Course language is .
Department offering the course: IFM.
Director of Studies: Stefan Svensson
Examiner: Nalle Jonsson

Course Syllabus in Swedish

Linköping Institute of Technology
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Contact: TFK , val@tfk.liu.se
Last updated: 05/27/2008