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COURSE TITLE

Free Radicals in Living Organisms, 7,5 points

COURSE CATEGORY   Programkurs/Fristående kurs MAIN FIELD OF STUDY   SUBJECT AREA     COURSE CODE   OMBFRO

AIM OF THE COURSE

Oxygen derived free radicals are indispensable for the defence against invading micro-organisms and important for cell signalling in living organisms. Overproduction of free radicals, however, will cause cellular damage that might result in mutations or cell death. The purpose of the course is to give in-depth knowledge about the balance between oxidative and reductive processes in living organisms. Present methods for detection and analysis of free radical producing reactions and understanding of problems and difficulties. Furthermore, the course will give a survey of free radical induced damage on macromolecular-, cell- and organism levels.

CONTENTS

* Free radical chemistry * Free radicals induced by irradiation and toxic substances * Cellular damage caused by free radicals; adaption, reparation and cell death * Free radicals and disease; atheriosclerosis, ischemia, diabetes and cancer * Nitric oxide and cellular signalling * Antioxidants * Gluthation and cellular redox systems * Importance of transition metals; iron metabolism * Defence against micro-organisms; inflammation * Redox reactions in plants; the chloroplast * Radiobiology * Detection methods (e.g. fingerprinting and trapping)

TEACHING

Lectures, tutorial groups, seminars and laboratory work. The educational method used is problem-based learning (PBL). PBL emphasises the student´s development of free, self-supporting, lifelong learning ability as an instrument for critical inquiry. The students own queries and formulated problems form the basis of PBL. Important is also the student´s ability to take responsibility for his/her own learning, and to seek and evaluate information and knowledge and to train co-operation and flexible attitude to different views and ideas.

EXAMINATION

Active participation in tutorial groups and seminars. Written examination. Students, which have not passed on the regular examination occasion, are normally offered four additional opportunities according to this syllabus, one of which is close in time to the first examination occasion. Students who have failed three times on the course or part of the course are entitled to request another examiner at the new examination occasion.

ADMISSION REQUIREMENTS

Bachelor of Science in Biomedicine or other related subjects such as Medicine or Biology. At least three years of full-time undergraduate studies in a relevant main subject. For students in the Medical Biology Programme, 160 credits: Passed semester 1 to 5. Obs! To be admitted to courses taught in English you must fulfil the requirement of at least one year of full-time undergraduate studies. Documented knowledge of English equivalent to "Engelska B" is required, or an international proficiency test, e.g. TOEFL, minimum score 550/213.

GRADING

CERTIFICATE

COURSE LITERATURE

The course literature is decided upon by the department in question.

OTHER INFORMATION

Free Radicals in Living Organisms Free Radicals in Living Organisms   Department responsible for the course or equivalent: MEDBIO - Medicinsk biologi             Registrar No:   Course Code: OMBFRO           Exam codes: see Local Computer System       Subject/Subject Area :                       Level   Education level     Subject Area Code   Field of Education   D       MBI   Naturvetenskap